論文リスト

■2021年〜2025年

Eltigani SA, Ohta C, Nakamiya R, Yokono M, Bito T, Takahashi K, Yabuta Y, Eltayeb MM, Ohta T, Ishihara A. Exploring volatiles and biological effects of Commiphora africana and Boswellia papyrifera incense. Molecules 30, 499 (2025)

Okabe S, Takahashi K, Hashimoto M, Ohta T. Nociceptive TRP channels function as molecular target for several antifungal drugs. Fundam Clin Pharmacol 38, 1178-1189 (2024)

Hashimoto M, Takahashi K, Ohta T. Analgesic effects of linalyl acetate via nociceptive TRPV1 inhibition in mice. Biomed Res 45, 217–230 (2024)

Kasuya K, Takahashi K, Hashimoto M, Ohta T. Nociceptive transient receptor potential ankyrin 1 (TRPA1) in sensory neurons are targets of the antifungal drug econazole. BMC Pharmacol Toxicol. 25:53 (2024)

Takahashi K, Tanaka T, Ishihara A, Ohta T. Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity. Discov Oncol 15:177 (2024)

Hashimoto M. Takahashi K, Unno T, Ohta T. Linalyl acetate exerts analgesic effects by inhibiting nociceptive TRPA1 in mice. Biomed Res 45:125-133 (2024)

Tanaka T, Takahashi K, Inoue Y, Endo N, Shimoda E, Ueno K, Ichiyanagi T, Ohta T, Ishihara A.　Inhibition of melanoma cell proliferation by strobilurins isolated from mushrooms and their synthetic analogues. Biosci Biotechnol Biochem 88, 389–398 (2024)

Nakagawa M, Takahashi K, Nishizawa Y, Ohta T. Involvement of interaction of Cav3.2 and nociceptive TRPA1 in pathological pain transmission. Biomed Res 45:45-55 (2024)

Pimpjong K, Matsuyama H, Mizutani T, Tanahashi Y, Ohta T, Unno T. Possible role of transient receptor potential melastatin 4 channels in adrenergic contractions in mouse prostate smooth muscles. J Vet Med Sci 85(7):705-714（2023）

Hashimoto M. Takahashi K, Ohta T. Inhibitory effects of linalool, an essential oil component of Lavender, on nociceptive TRPA1 and voltage-gated Ca²⁺ channels in mouse sensory neurons. Biochem Biophys Reports 34:101468 (2023)

Saito S, Saito CT, Igawa T, Takeda N, Komaki S, Ohta T, Tominaga M. Evolutionary tuning of TRPA1 underlies the variation in heat avoidance behaviors among frog species inhabiting diverse thermal niches. Mol Biol Evol 39:1-18 (2022)

Yoshimura A, Saito S, Saito C, Takahashi K, Tominaga M, Ohta T. Functional analysis of thermo-sensitive TRPV1 in an aquatic vertebrate, masu salmon (Oncorhynchus masou ishikawae). Biochem Biophys Reports 31:101315 (2022)

Oka Y, Takahashi K, Ohta T. The effects of vanilloid analogues structurally related to capsaicin on the transient receptor potential vanilloid 1 channel. Biochem Biophys Reports 30:101243 (2022)

Oguma N, Takahashi K, Okabe S, Ohta T. Inhibitory effect of polysulfide, an endogenous sulfur compound, on oxidative stress-induced TRPA1 activation. Neurosci Lett 757:135982 (2021)

■2016年〜2020年

Uzura R, Takahashi K, Saito S, Tominaga M, Ohta T. Reduction of extracellular sodium evokes nociceptive behaviors in the chicken via activation of TRPV1. Brain Res 1747: 147052 (2020)

Shimada T, Takahashi K, Tominaga M, Ohta T. Identification of molecular targets for toxic action by persulfate, an industrial sulfur compound. Neurotoxicol 72:29-37 (2019)

Majikina A, Takahashi K, Saito S, Tominaga M, Ohta T. Involvement of nociceptive transient receptor potential channels in repellent action of pulegone. Biochem Pharmacol 151, 89-95. (2018)

Nishizawa Y, Takahashi K, Oguma N, Tominaga M, Ohta T. Possible involvement of transient receptor potential ankyrin 1 in Ca2+ signaling via T-type Ca2+ channel in mouse sensory neurons.　J Neurosi Res 96:901-910. (2018)

Takahashi K, Ohta T. Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells. Biochem Biophys Res Commun 490, 587-593 (2017)

Miyake K., Ohta T., Nakayama H., Doe N., Terao Y., Oiki E., Nagatomo I., Yamashita Y., Abe T., Nishikura K., Kumanogoh A., Hashimoto K., Kawahara Y. CAPS1 RNA editing promotes dense core vesicle exocytosis. Cell Reports 17, 2004-2014. (2016)

Yamamoto A, Takahashi K, Saito S, Tominaga M, Ohta T. Two different avian cold-sensitive sensory neurons: transient receptor potential melastatin 8 (TRPM8)-dependent and -independent activation mechanisms. Neuropharmacol, 111:130-141. (2016)

Suzawa S, Takahashi K, Shimada T and Ohta T. Carbonyl stress-induced 5-hydroxytriptamine secretion from RIN-14B, rat pancreatic islet tumor cells, via the activation of transient receptor potential ankyrin 1. Brain Res Bull, 125:181-186. (2016)

Saito S, Ohkita M, Saito C.T, Takahashi K, Tominaga M, Ohta T. Evolution of heat sensors drove shifts in thermosensation between xenopus species adapted to different thermal niches. J Biol Chem, 291(21):11446-11459. (2016)

Kaimoto T, Hatakeyama Y, Takahashi K, Imagawa T, Tominaga M, *Ohta T. Involvement of transient receptor potential A1 channel in algesic and analgesic actions of the organic compound limonene. Eur J Pain, 20(7):1155-1165. (2016)

Delgermurn D, Ito S, Ohta T, Yamaguchi S, Otsuguro K. Endogenous 5-HT outflow from chicken aorta by 5-HT uptake inhibitors and amphetamine derivatives J Vet Med Sci (2016) 78(1):71-76.

■2010年〜2015年

Hatakeyama Y, Takahashi K, Tominaga M, Kiumura H, Ohta T. Polysulfide evokes acute pain through the activation of nociceptive TRPA1 in mouse sensory neurons. Molecular Pain11:24. (2015)

Banzawa N., Saito S., Imagawa T., Kashio M., Takahashi K., Tominaga M., Ohta T., Molecular Basis Determining Inhibition/Activation of Nociceptive Receptor TRPA1: A Single Amino Acid Dictates Species-specific Actions of the Most Potent Mammalian TRPA1 Antagonist. J Biol Chem 289(46):31927-31939.（2014） .

Takahashi K, Yokota M, Ohta T. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12. Exp Cell Res 323(2):337-345. (2014)

Saito S, Banzawa N, Fukuta N, Takahashi K, Imagawa T, Ohta T, Tominaga M. Heat and noxious chemical sensor, chicken TRPA1, as a target of bird repellents and identification of its structural determinants by multispecies functional comparison. Mol Biol Evol 31(3):708–722. (2014)

Nakatsuka K, Gupta R, Saito S, Banzawa N, Takahashi K, Tominaga M, Ohta T Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences. J Mol Neurosci 51(3):754-762. (2013)

Takahashi K, Ohta T　Inflammatory acidic pH enhances hydrogen sulfide-induced TRPA1 activation in RIN-14B cells. J. Neurosci. Res (2013) 1322-1327

Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M and Ohta　T. Involvement of TRPA1 activation in acute pain induced by cadmium in mice. Molecular Pain 9:7, Feb (2013)

Iwasaki T, Otsuguro KI, Kobayashi T, Ohta T, Ito S. Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT(2A) and 5-HT(3) receptors. Eur J Pharmacol. 702(1-3):149-157　(2013).

Takahashi K, Ohta T. Low pH enhances 2-aminoethoxydiphenyl borate-induced cell death of PC12 cells. Toxicol Lett. 215(7) 161-166.（2012）

Omori A, Hirai M, Chiba T, Takahashi K, Yamaguchi S, Takahashi TA, Kashiwakura I. Quality-assessments of characteristics of placental/umbilical cord blood associated with maternal age- and parity-related factor. Transfus Apher Sci. 46(1):7-13（2012）

Saito S, Nakatsuka K, Takahashi K, Fukuta N, Imagawa T, Ohta T, Tominaga M.　Analysis of Transient Receptor Potential Ankyrin 1 (TRPA1) in Frogs and Lizards Illuminates Both Nociceptive Heat and Chemical Sensitivities and Coexpression with TRP vanilloid 1 (TRPV1) in Ancestral Vertebrates. J Biol Chem. 287(36): 30743-30754, Aug (2012)..

Ogawa H, Takahashi K, Miura S, Imagawa T, Saito S, Tominaga M, Ohta T. H2S functions as a nociceptive messenger through transient receptor potential ankyrin 1 (TRPA1) activation. Neuroscience. 218:335-343, May (2012).

Ohkita M, Saito S, Imagawa T, Takahashi K, Tominaga M, Ohta T. Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal its functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates. J Biol Chem. 287(4):2388-97. （2012）

Omori A, Hirai M, Chiba T, Takahashi K, Yamaguchi S, Takahashi TA, Kashiwakura I. Quality-assessments of characteristics of placental/umbilical cord blood associated with maternal age- and parity-related factor.　Transfus Apher Sci. 46(1):7-13　（2012）;.

Chai H, Hazawa M, Shirai N, Igarashi J, Takahashi K, Hosokawa Y, Suga H, Kashiwakura I. Functional properties of synthetic N-acyl-L-homoserine lactone analogs of quorum-sensing gram-negative bacteria on the growth of human oral squamous carcinoma cells. Invest New Drugs. 30(1):157-63　（2012）.

Yoshino H, Watanabe N, Takahashi K, Ogura K, Akagi T, Kubo K, Kashiwakura I.The potential of patients' peripheral blood mononuclear cells to differentiate into dendritic cells after hematopoietic stem cell transplantation. Life Sci. 89(25-26):946-55（2011）.

Monzen S, Takahashi K, Yoshino H, Kasai-Eguchi K, Kashiwakura I. Terminal maturation of megakaryocytes and platelet production by hematopoietic stem cells irradiated with heavy-ion beams. Radiat Res. 176(1):8-16　（2011）.

Hazawa M, Takahashi K, Sugata S, Kashiwakura I. (-)-Epigallocatechin-3-O-gallate induces nonapoptotic cell death in leukemia cells independent of the 67 kDa laminin receptor. J Nat Prod. 74(4):695-700　（2011）.

Hazawa M, Kudo M, Iwata T, Saito K, Takahashi K, Igarashi J, Suga H, Kashiwakura I. Caspase-independent apoptosis induction of quorum-sensing autoinducer analogs against chronic myeloid leukemia K562. Invest New Drugs. 30(3):862-9（2011）.

Fukushi Y, Hazawa M, Takahashi K, Yoshizawa A, Kashiwakura I. Liquid crystal-related compound-induced cell growth suppression and apoptosis in the chronic myelogenous leukemia K562 cell line. Invest New Drugs. （2011） Oct;29(5):827-32.

Takahashi Y, Hazawa M, Takahashi K, Nishizawa A, Yoshizawa A, Kashiwakura I. Suppressive effects of liquid crystal compounds on the growth of the A549 human lung cancer cell line. Invest New Drugs. 29(4):659-65　（2011）.

Wada K, Hazawa M, Takahashi K, Mori T, Kawahara N, Kashiwakura I. Structure-activity relationships and the cytotoxic effects of novel diterpenoid alkaloid derivatives against A549 human lung carcinoma cells. J Nat Med. 65(1):43-9　（2011）.

Ohta T, Ohba T, Suzuki T, Watanabe H, Sasano H, Murakami M. Decreased calcium channel currents and facilitated epinephrine release in the Ca²⁺ channel β3 subunit-null mice. Biochem Biophys Res Commun.394(3):464-469. Apr. (2010)

Kajihara Y, Murakami M, Imagawa T, Otsuguro K, Ito S, Ohta T. Histamine potentiates acid-induced responses mediating transient receptor potential V1 (TRPV1) in mouse primary sensory neurons. Neuroscience, 166(1):292-304.Mar. (2010)

Takahashi T, Otsuguro K, Ohta T, Ito S. Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats. Br J Pharmacol. 161(8):1806-16　（2010）.

Chiba T, Omori A, Takahashi K, Tanaka K, Kudo K, Manabe M, Mariya Y, Kashiwakura I. Correlations between the detection of stress-associated hormone/oxidative stress markers in umbilical cord blood and the physical condition of the mother and neonate. J Obstet Gynaecol Res. 2010 Oct;36(5):958-64.

Hayashi N, Takahashi K Kashiwakura I. The effects of X-irradiation on ex vivo expansion of cryopreserved human hematopoietic stem/progenitor cells. J Radiat Res. 51, 137-144, Mar. (2010).

Kato K, Takahashi K, Monzen S, Yamamoto H, Maruyama A, Itoh K, Kashiwakura I. Relationship between radiosensitivity and Nrf2 target gene expression in human hematopoietic stem cells. Radiat Res. 2010 Aug;174(2):177-84.

Takahashi K, Monzen S, Hayashi N, Kashiwakura I. Correlations of cell surface antigens with the individual differences of radio-sensitivity in human hematopoietic stem/progenitor cells. Radiat Res. 173, 184-190, Feb. (2010).

Yoshino H, Takahashi K, Monzen S, Kashiwakura I.Proteoglycans regulate the chemotaxis of dendritic cells derived from human peripheral blood monocytes. Biol Pharm Bull. 2010;33(6):938-44.

Yoshino H, Takahashi K, Monzen S, Kashiwakura I. Effects of proteoglycan extracted from the nasal cartilage of salmon heads on the maturation of dendritic cells derived from human peripheral blood monocytes. Biol Pharm Bull. 33, 311-315, Feb. (2010).

Kudo K, Liu Y, Takahashi K, Tarusawa K, Hu D-L, Kashiwakura I, Kijima H, Nakane A. Transplantation of mesenchymal stem cells to prevent radiation-induced intestinal injury in mice. J Radiat Res. 51, 73-79, Feb. (2010).

Omori A, Manabe M, Kudo K, Tanaka K, Takahashi K, Kashiwakura I. Influence of obstetric factors on the yield of mononuclear cells, the CD34+ cell count and the volume of placental/umbilical cord blood. J Obstet Gynaecol Res. 36, 52-57, Feb. (2010).

■2005年　〜　2009年

Murakami M, Ohta T, Ito S. Lipopolysaccharides enhance the actionof bradykinin in enteric neurons via secretion of interleukin-1β fromenteric glial cells. J. Neurosci. Res. 87(9):2095-2104, Jul. (2009)

Otsuguro K, Yasutake S, Yamaji Y, Ban M, Ohta T, Ito S. Roles ofpurines in synaptic modulation evoked by hypercapnia in isolated spinal cordof neonatal rat in vitro. Br. J. Pharmacol. 156(7):1167-1177. Apr. (2009)

Ohta T, Imagawa T, Ito S. Involvement of transient receptor potential vanilloid subtype 1 (TRPV1) in analgesic action of methylsalicylate. Mol. Pharmacol. 75, 307-317, Feb.(2009).

Hazawa M, Takahashi K, Wada K, Mori T, Kawahara N, Kashiwakura I. Structure-activity relationships between the Aconitum C₂₀-diterpenoid alkaloid derivatives and the growth suppressive activities of Non-Hodgkin’s lymphoma Raji cells and human hematopoietic stem/progenitor cells. Invest New Drugs. Sep. (2009). (Epub ahead of print).

Katsumori T, Yoshino H, Hayashi M, Takahashi K, Kashiwakura I. Inductive potential of recombinant human granulocyte colony-stimulating factor mature neutrophils from X-irradiated human peripheral blood hematopoietic progenitor cells. Biol Pharm Bull. 32, 1849-1853, Nov. (2009).

Monzen S, Takahashi K, Yoshino H, Kasai-Eguchi K, Abe Y, Maruyama A, Itoh K, Kashiwakura I. Heavy ion beam irradiation regulates mRNA expression in megakaryocytopoiesis from human hematopoietic stem/progenitor cells. J Radiat Res. 50, 477-486, Sep. (2009).

Monzen S, Osuda K, Miyazaki Y, Hayashi N, Takahashi K, Kashiwakura I. Radiation sensitivities in the terminal stages of megakaryocytic maturation and platelet production. Radiat Res. 172, 314-320, Sep. (2009).

Terasawa R, Fukushi Y, Monzen S, Miura T, Takahashi K, Yoshizawa A, Kashiwakura I. The promoting activity on human megakaryocytopoiesis and thrombopoiesis by liquid crystal-related compounds. Biol Pharm Bull. 32, 976-981, Jun. (2009).

Monzen S, Takahashi K, Toki T, Ito E, Sakurai T, Miyakoshi J, Kashiwakura I. Exposure to a MRI-type high-strength static macnetic field stimulates megakaryocytic/erythroid hematopoiesis in CD34⁺ cells from human placental and umbilical cord blood. Bioelectromagnetics. 30, 280-285, May. (2009).

Hazawa M, Wada K, Takahashi K, Mori T, Kawahara N, Kashiwakura I. Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth. Invest New Drugs. 27, 111-119, Apr. (2009).

Hayashi N, Takahashi K, Abe Y, Kashiwakura I. Placental/umbilical cord blood-derived mesenchymal stem cell-like stromal cells support hematopoietic recovery of X-irradiated human CD34⁺ cells. Life Sci. 84, 598-605, Apr. (2009).

Ohta T, Imagawa T, Ito S. Novel gating and sensitizing mechanism of capsaicin receptor (TRPV1): Tonic inhibitory regulation of extracellular sodium through the external protonation sites on TRPV1. J. Biol. Chem. 283, 9377-9387, Apr. (2008).

Ishida T, Takei R, Gautam SH, Otsuguro K, Ohta T, Ito S, Habara Y, Saito, T. Voltage-gated channel properties of epithelial cells in porcine vomeronasal organ. Neurosci. Lett. 441, 277-281, Aug. (2008).

Murakami M, Ohta T, Ito S. Interleukin 1beta enhances the action of bradykinin in rat myenteric neurons through upregulation of glial B1 receptor expression. Neuroscience. 151, 222-231, Jan. (2008).

Takahashi K, Monzen S, Yoshino H, Abe Y, Eguchi-Kasai K, Kashiwakura I. Effects of a 2-step culture with cytokine combinations on megakaryocytopoiesis and thrombopoiesis from carbon-ion beam-irradiated human hematopoietic stem/progenitor cells. J Radiat Res. 49, 417-424, Jul. (2008).

Omori A, Takahashi K, Hazawa M, Misaki N, Ohba H, Manabe M, Sato H, Kudo K, Takahashi T A, Kashiwakura I. Maternal and neonatal factors associated with the high yield of mononuclear low-density/CD34⁺ cells from placental/umbilical cord blood. Tohoku J Exp Med. 215, 23-32, May. (2008).

Kashiwakura I, Takahashi K, Monzen S, Nakamura T, Takagaki K. Ex vivo expansions of megakaryocytopoiesis from placental and umbilical cord blood CD34⁺ cells in serum-free culture supplemented with proteoglycans extracted from the nasal cartilage of salmon heads and the nasal septum cartilage of whale. Life Sci. 82, 1023-1031, May. (2008).

Yoshino H, Takahashi K, Monzen S, Kashiwakura I. Differential induction from X-irradiated human peripheral blood monocytes to dendritic cells. J Radiat Res. 49, 293-303, May. (2008).

Oriya A, Takahashi K, Inanami O, Miura T, Abe Y, Kuwabara M, Kashiwakura I. Individual differences in the radiosensitivity of hematopoietic progenitor cells detected in steady-state human peripheral blood. J Radiat Res.49, 133-121, Mar. (2008).

Ohta T, Imagawa T, Ito S. Novel agonistic action of mustard oil on recombinant and endogenous porcine Transient Receptor Potential V1 (pTRPV1) channels. Biochem. Pharmacol. 73, 646-656, May (2007).

Murakami M, Ohta T, Otsuguro K, Ito S. Involvement of prostaglandin E2 derived from enteric glial cells in the action of bradykinin in cultured rat myenteric neurons. Neuroscience. 145, 642-653, Mar. (2007).

Wada K, Hazawa M, Takahashi K, Mori T, Kawahara M, Kashiwakura I. Inhibitory effects of diterpenoid alkaloids on the growth of A172 human malignant cells. J Nat Prod. 70, 1854-1858, Dec. (2007).

Takahashi K, Monzen S, Eguchi-Kasai K, Abe Y, Kashiwakura I. Severe damage of human megakaryocytopoiesis and thrombopoiesis by heavy-ion beam radiation. Radiat Res. 168, 545-551, Nov. (2007).

Kashiwakura I, Takahashi K, Takagaki K. Application of proteoglycan extracted from the nasal cartilage of salmon heads for ex vivo expansion of hematopoietic progenitor cells derived from human umbilical cord blood. Glycoconj J. 24, 251-258, Jul. (2007).

Ohta T, Ikemi Y, Murakami M, Imagawa T, Otsuguro K, Ito S. Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-hydroxytryptamine receptors in rat primary sensory neurons. J. Physiol. 576, 809-822, Aug. (2006).

Takahashi E, Inanami O, Ohta T, Matsuda A, Kuwabara M. Lipid raft disruption prevents apoptosis induced by 2-chloro-2'-deoxyadenosine (Cladribine) in leukemia cell lines. Leuk. Res. 30, 1555-1561, Dec. (2006).

Otsuguro K, Yamaji Y, Ban M, Ohta T, Ito S. Involvement of adenosine in depression of synaptic transmission during hypercapnic acidosis in isolated spinal cord of neonatal rats. J. Physiol. 574, 835-847, Aug. (2006).

Otsuguro K, Ohta T, Ito S. Zinc modulates primary afferent fiber-evoked responses of ventral roots in neonatal rat spinal cord in vitro. Neuroscience. 138, 281-191, Mar. (2006).

Zhang X, Soda Y, Takahashi K, Bai Y, Mitsuru A, Igura K, Satoh H, Yamaguchi S, Tani K, Tojo A, Takahashi T A. Successful immortalization of mesenchymal progenitor cells derived from human placenta and the differentiation abilities of immortalized cells. Biochem Biophys Res Commun. 351, 853-859, Dec. (2006).

Monzen S, Mori T, Takahashi K, Abe Y, Inanami O, Kuwabara M, Kashiwakura I. The effects of (-)-epigallocatechin-3-gallate on the proliferation and differentiation of human megakaryocytic progenitor cells. J Radiat Res. 47, 213-220, Jun. (2006).

Zhang X, Mitsuru A, Igura K, Takahashi K, Ichinose S, Yamaguchi S, Takahashi T A. Mesenchymal progenitor cells derived from chorionic villi of human placenta for cartilage tissue engineering. Biochem Biophys Res Commun. 340, 944-952, Feb. (2006).

Ohta T, Komatsu R, Imagawa T, Otsuguro K, Ito S. Molecular cloning, functional characterization of the porcine transient receptor potential V1 (pTRPV1) and pharmacological comparison with endogenous pTRPV1. Biochem. Pharmacol. 71, 173-187, Dec. (2005).

Ohta T, Kubota A, Murakami M, Otsuguro K, Ito S. P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons. Am. J. Physiol. Gastrointest. Liver Physiol. 298, G935-G948, May (2005).